Do you think I got this right? It seems you are unfamiliar with the literature. I would say that reason is what is telling us that we should be concerned. This page was last edited on 25 March , at Retrieved 14 November Learn how your comment data is processed.
He is the George B. Do you think I got this right? The authors are from Northwestern, i. The author is a journalist working for the magazine, not a practicing scientist. Fill in your details below or click an icon to log in: Wrighton on microelectrode devices for electrocatalysis. It seems you are unfamiliar with the literature.
SmartFlares are a very minor part of the article.
In other projects Wikimedia Commons. This page was last edited cahd 25 Marchat The former have a plausible though certainly not well characterized mechanism: Like Liked by 1 person. Let me refine those last sentences: Sorry, your blog cannot share posts by email. Antisense gene regulation cannot happen without the particles going out of the endosomes.
Mirkin is known for his development of nanoparticle-based biodetection schemes, mirkib invention of dip-pen nanolithography recognized by National Geographic as one of the top scientific discoveries that changed the worldand contributions to supramolecular chemistry, nanoelectronics, and nanooptics.
I think the distinction of peer-reviewed vs otherwise is not useful.
Rathmann professor of chemistry, professor of medicine, chax of materials science and engineeringprofessor of biomedical engineeringand professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.
From Wikipedia, the free encyclopedia. He is the founding editor of the nanotechnology journal Smalland he is an associate editor of the Journal of the American Chemical Society.
Chad Alexander Mirkin born November 23, is an American chemist. Do the oligonucleotides enter with or without the AuNPs?
A RESPONSE FROM CHAD MIRKIN’S GROUP [follow up #1/n] | Rapha-z-lab
Yes, your summary is pretty much what I was getting at. And no, the papers on nano-flares are not underpinning the clinical trials, the papers on gene regulation are.
Royal Society of Chemistry. I am not sure if I am repeating a citation that is already been thhesis in this post but low pH seems to stabilize the S-AuNP bond: It assumes it does. Leave a Reply Cancel reply Enter your comment here Phoenix, ArizonaU.
I happen to agree with you that the flares lighting up in the endosome is a serious issue to be addressed and most certainly interferes with accurate detection of mRNA. Well, you said it yourself: They are being tested for antisense gene regulation, which has been demonstrated both in vivo and in vitro. Chas may only be a couple mRNA thseis in the cytosol that need to interact with a complementary oligo in order to observe knockdown.
Chad Mirkin – Wikipedia
The author is a journalist working for the magazine, not a practicing scientist. Inhe was listed as the most cited chemist in the world over the last decade in terms of total citations, the second highest most cited chemist  in terms of impact factor,  and the top most cited nanomedicine researcher. Notify me of new comments via email.
This is the most basic, surprising, unexpected and critical feature of these materials. If desorption occurs due to breaking of the Au-S bond, there cannot be specificity.
Wrighton on microelectrode devices for electrocatalysis. It does not show in any way that SmartFlares work.
Learn how your comment data is processed. Mirkin was born November 23,in Phoenix, Arizona. Retrieved 14 November Email Address never made public.